Billy Li , Sites by Parallel DNA Capturing and Sequencing Genome - Wide Identification of Human RNA Editing
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منابع مشابه
Genome-wide identification of human RNA editing sites by parallel DNA capturing and sequencing.
Adenosine-to-inosine (A-to-I) RNA editing leads to transcriptome diversity and is important for normal brain function. To date, only a handful of functional sites have been identified in mammals. We developed an unbiased assay to screen more than 36,000 computationally predicted nonrepetitive A-to-I sites using massively parallel target capture and DNA sequencing. A comprehensive set of several...
متن کاملAccurate identification of A-to-I RNA editing in human by transcriptome sequencing.
RNA editing enhances the diversity of gene products at the post-transcriptional level. Approaches for genome-wide identification of RNA editing face two main challenges: separating true editing sites from false discoveries and accurate estimation of editing levels. We developed an approach to analyze transcriptome sequencing data (RNA-seq) for global identification of RNA editing in cells for w...
متن کاملA-to-I RNA editing occurs at over a hundred million genomic sites, located in a majority of human genes.
RNA molecules transmit the information encoded in the genome and generally reflect its content. Adenosine-to-inosine (A-to-I) RNA editing by ADAR proteins converts a genomically encoded adenosine into inosine. It is known that most RNA editing in human takes place in the primate-specific Alu sequences, but the extent of this phenomenon and its effect on transcriptome diversity are not yet clear...
متن کاملRES-Scanner: a software package for genome-wide identification of RNA-editing sites
BACKGROUND High-throughput sequencing (HTS) provides a powerful solution for the genome-wide identification of RNA-editing sites. However, it remains a great challenge to distinguish RNA-editing sites from genetic variants and technical artifacts caused by sequencing or read-mapping errors. RESULTS Here we present RES-Scanner, a flexible and efficient software package that detects and annotat...
متن کاملRADAR: a rigorously annotated database of A-to-I RNA editing
We present RADAR--a rigorously annotated database of A-to-I RNA editing (available at http://RNAedit.com). The identification of A-to-I RNA editing sites has been dramatically accelerated in the past few years by high-throughput RNA sequencing studies. RADAR includes a comprehensive collection of A-to-I RNA editing sites identified in humans (Homo sapiens), mice (Mus musculus) and flies (Drosop...
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تاریخ انتشار 2009